Xiuping Yu, Ph.D.

Assistant Professor

Contact Information:

Email: xyu@lsuhsc.edu
Office Phone: 318-675-4331
Laboratory Phone: 318-675-7867
Office Fax: 318-675-5180


B.S., 1991, Nankai University, Tianjin, China
Ph.D., 2000 Dalian Medical University, Dalian, China

Major Research Interests:  

My major research focus is on prostate cancer - specifically the mechanism by which prostate cancer becomes resistant to androgen deprivation therapy.

My research primarily focuses on the role of Wnt/beta-catenin Signaling and Foxa proteins (Foxa1 and Foxa2) in prostate development and cancer progression. Specifically, my research on prostate cancer focuses on progression to castration resistance, a major cause for disease-specific mortality in men with prostate cancer. I use both in vitro and in vivo models. For my in vivo studies, I use genetically engineered mouse models, as well as a novel tissue recombination xenografting approach. My long-term research interest is to understand the mechanisms through which prostate cancer initiates and progresses, with an ultimate goal of identifying potential therapeutic targets for treating advanced prostate cancer.


  1. Androgen receptor differentially regulates the proliferation of prostatic epithelial cells in vitro and in vivo.
  2. Inhibition of NF-kappa B signaling restores responsiveness of castrate-resistant prostate cancer cells to anti-androgen treatment by decreasing androgen receptor-variant expression.
  3. SOX2 expression in the developing, adult, as well as, diseased prostate.
  4. Activation of Wnt/β-catenin signaling in a subpopulation of murine prostate luminal epithelial cells induces high grade prostate intraepithelial neoplasia.
  5. Mouse models of prostate cancer: picking the best model for the question.

All Publications: PubMed