Xiuping Yu, Ph.D.

Assistant Professor


Contact Information:

Email: xyu@lsuhsc.edu
Office Phone: 318-675-4331
Laboratory Phone: 318-675-7867
Office Fax: 318-675-5180

Education/Training:

B.S., 1991, Nankai University, Tianjin, China
Ph.D., 2000 Dalian Medical University, Dalian, China

Major Research Interests:  

My major research focus is on prostate cancer - specifically the mechanism by which prostate cancer becomes resistant to androgen deprivation therapy.

My research primarily focuses on the role of Wnt/beta-catenin Signaling and Foxa proteins (Foxa1 and Foxa2) in prostate development and cancer progression. Specifically, my research on prostate cancer focuses on progression to castration resistance, a major cause for disease-specific mortality in men with prostate cancer. I use both in vitro and in vivo models. For my in vivo studies, I use genetically engineered mouse models, as well as a novel tissue recombination xenografting approach. My long-term research interest is to understand the mechanisms through which prostate cancer initiates and progresses, with an ultimate goal of identifying potential therapeutic targets for treating advanced prostate cancer.

RepresentativePublications:

  1. Androgen receptor differentially regulates the proliferation of prostatic epithelial cells in vitro and in vivo.
  2. Inhibition of NF-kappa B signaling restores responsiveness of castrate-resistant prostate cancer cells to anti-androgen treatment by decreasing androgen receptor-variant expression.
  3. SOX2 expression in the developing, adult, as well as, diseased prostate.
  4. Activation of Wnt/β-catenin signaling in a subpopulation of murine prostate luminal epithelial cells induces high grade prostate intraepithelial neoplasia.
  5. Mouse models of prostate cancer: picking the best model for the question.

All Publications: PubMed